Research Area A is devoted to the understanding of the general and specific mechanisms in chronic liver damage (specifically viral infection and chronic inflammation) that predispose to or initiate the development of HCC and that may offer prospects for preventive measures and intervention. The main focus will be on chronic hepatitis and its sequelae.
A1: Impact of Hepatitis C Virus Core and NS5A on the Induction of Pro-carcinogenic Alterations and HCC Development (Lohmann/Bartenschlager)
A2: The role of Reactive Oxygen Species in Hepatocarcinogenesis (Gülow/Krammer)
A6: Dissecting TGF-b Signaling in Hepatocarcinogenesis (Dooley/Meindl-Beinker)