ProjectsHepatocellular carcinoma (HCC) is one of the most frequent and dismal malignancies with so far limited therapeutic options but also an ideal model system for tumour research and the most relevant paradigm for virus-induced and inflammation-mediated cancer. Recent progress has demonstrated the feasibility of translating basic biomedical research findings into HCC therapy. The main aim of the SFB/TRR77 is to gain a profound understanding of the molecular basis of human hepatocarcinogenesis beginning with its initiation from chronic liver disease to its progression into metastatic cancer, its functional dissection and the identification of novel preventive, diagnostic, and therapeutic approaches by concentrating on three main goals:
- to understand general and specific mechanisms of chronic liver diseases (specifically chronic viral infection and inflammation-mediated processes) that predispose to or initiate the liver cancer and may lead to new preventive strategies (Research Area A).
- to identify and functionally characterize key molecular events that promote or sustain liver cancer and thus may serve as markers for tumour relevant functions or that may unravel promising mechanisms and targets for future therapeutic intervention (Research Area B).
- to functionally dissect specific tumor-relevant mechanisms already identified in previous research, to explore modes of translation and improve tumor targeting (Research Area C).
- DFG-funded projects that are thematically linked to the SFB/TRR77 (and located in Heidelberg or Hannover) can be associated to the SFB/TRR77 following application and decision by the Steering committee and with this take part in all events of the SFB/TRR77 (Associated Projects).
- The Project Area Z has a supportive and service function for the whole SFB/TRR77-consortium. Winthin Project Z1 all administrative issues are covered, the Project Z2 offers bioinformatical support and expertise for all.