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Project A5

Role of c-myc in Chronic Liver Injury and Hepatocarcinogenesis

Principal Investigator: PD Dr. med. Arndt Vogel

 

 

Short Summary

Deregulated expression of c-myc is a frequent event in human liver cancers. The aim of this project is to analyze the role of c-myc in hepatocytes during chronic injury and to specify the role of c-myc in the promotion of hepatocellular transformation. A systematic functional analysis of c-myc effects in mouse HCC models will be accomplished by microarray analysis to dissect the role of c-myc in hepatocarcinogenesis and to identify underlying molecular mechanisms. Cross species comparisons will be performed to validate c-myc targets in human hepatocarcinogenesis.

 

List of relevant publications

  1. Buitrago-Molina LE, Lamlè J, Marhenke S, Schüngel S, Kossatz U, Breuhahn K, Manns MP, Malek N, Vogel A Rapamycin prevents proliferation of damaged hepatocytes during chronic liver injury and thereby liver tumor development. Hepatology (accepted)
  2. Marhenke S, Buitrago L, Yamamoto M, Manns MP, Grompe M, Vogel A (2008) Activation of Nrf2 in hereditary type 1 and its role in survival and liver tumor development. Hepatology 48:487-96.
  3. Lamlé J, Marhenke S, Borlak S, von Wasielewski S, Peter Eriksson CJ, GeffersR, Manns MP, Yamamoto M, Vogel A (2008) Nrf2 prevents alcohol-induced fulminant liver injury. Gastroenterology 134:1159-68.
  4. Willenbring H, Sharma A, Vogel A, Young Lee A, Rothfuss A, Finegold M, Grompe M (2008) Loss of p21 Permits Carcinogenesis from Chronically Damaged Liver and Kidney Epithelial Cells Despite Unchecked Apoptosis. Cancer Cell 14:59-67
  5. Vogel A, Aslan J, Willenbring H, Finegold M, Thomas G, Grompe M (2006) Phosphorylation of Bid and apoptosis sensitivity in the liver. Gastroenterology 130:104–119
  6. Vogel A, Van Den Berg I, Al-Dhalimy M, Groopman J, Ou C, Ryabinina O, Iordanov M, Finegold M, Grompe M (2004) Chronic liver disease in murine hereditary tyrosinemia type 1 induces resistance to cell death. Hepatology 39:433-43
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