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AWARDS & HONORS 2014

TOP PUBLICATIONS 2014


AWARDS & HONORS 2013:


TOP PUBLICATIONS 2013

  • Pellegrino R, Calvisi DF, Neumann O, Kolluru V, Wesely J, Chen X, Wang C, Wuestefeld T, Ladu S, Elgohary N, Bermejo JL, Radlwimmer B, Zörnig M, Zender L, Dombrowski F, Evert M, Schirmacher P, Longerich T. (2013) EEF1A2 inactivates p53 via PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma. Hepatology. doi: 10.1002/hep.26954. (projects B4, B5, Z2)
  • Hämmerle M, Gutschner T, Uckelmann H, Ozgur S, Fiskin E, Groß M, Skawran B, Geffers R, Longerich T, Breuhahn K, Schirmacher P, Stoecklin G, Diederichs S (2013) Post-transcriptional destabilization of the liver-specific long non-coding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1). Hepatology 2013 May 31. doi: 10.1002/hep.26537 (Projects B2, B3, B4, B5, B7)
  • T Wuestefeld, M Pesic, T Longerich, TW Kang, T Yevsa, D Dauch, A Potapova, Ina Rittelmeier, M Jarek, R Geffers, M Scharfe , F Klawonn, NP Malek, P Schirmacher, M Ott, A Vogel, MP Manns, Zender L (2013) A direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration. Cell 153(2):389-401 (Projects A4, A5, B4, B5, B8)
  • Buitrago-Molina LE, Marhenke S, Longerich T, Sharma AD, Boukouris AE, Geffers R, Guigas B, Manns MP, Vogel A (2013) The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis. Hepatology doi: 10.1002/hep.26412. (Projects A4, A5, B4, B5)
  • Pusterla T, Nèmeth J, Stein I, Wiechert L, Knigin D, Marhenke S, Longerich T, Kumar V, Arnold B, Vogel A, Bierhaus A, Pikarsky E, Hess J, Angel P (2013) Receptor for advanced glycation endproducts (RAGE) is a key regulator of oval cell activation and inflammation-associated liver carcinogenesis in mice. Hepatology. 58(1):363-73. (Projects A5, A7, B5)

 

AWARDS & HONORS 2012:


TOP PUBLICATIONS 2012

Singer S, Zhao R, Barsotti AM, Ouwehand A, Fazollahi M, Coutavas E, Breuhahn K, Neumann O, Longerich T, Pusterla T, Powers MA, Giles KM, Leedman PJ, Hess J, Grunwald D, Bussemaker HJ, Singer RH, Schirmacher P, Prives C. (2012) Nuclear Pore Component Nup98 Is a Potential Tumor Suppressor and Regulates Posttranscriptional Expression of Select p53 Target Genes. Mol Cell. 48(5):799-810. (A7, B5, B7, C5)

Wahl K
, Siegemund M, Lehner F, Vondran F, Nüssler A, Länger F, Krech T, Kontermann R, Manns MP, Schulze-Osthoff K, Pfizenmaier K, Bantel H. (2012) Increased apoptosis induction in hepatocellular carcinoma by a novel tumor-targeted TRAIL fusion protein combined with bortezomib. Hepatology 57(2):625-36 (C1, A4)

Malz M, Aulmann A, Samarin J, Bissinger M, Longerich T, Schmitt S, Schirmacher P, Breuhahn K. (2012) Nuclear accumulation of seven in absentia homologue (SIAH)-2 supports motility and proliferation of liver cancer cells Int J cancer 131(9):2016-26 (projects B5, B7)

 

Serres MP, Kossatz U, Chi Y, Roberts JM, Malek NP, Besson A. (2012) p27Kip1 controls cytokinesis via the regulation of citron kinase activation. J Clin Invest. 122(3):844-58. (project B8)

 

Longerich T, Mueller MM, Breuhahn K, Schirmacher P, Benner A, Heiss C (2012) Oncogenetic tree modeling of human hepatocarcinogenesis. Int J Cancer. 130(3):575-83. (projects B5, B7)

 

Malz M, Pinna F, Schirmacher P, Breuhahn K. (2012) Transcriptional regulators in hepatocarcinogenesis - key integrators of malignant transformation. J Hepatol. 57(1):186-95. (projects B5, B7)

 

Geraud C, Evdokimov K, Straub BK, Peitsch WK, Demory A, Dörflinger Y, Schledzewski K, Schmieder A, Schemmer P, Augustin HG, Schirmacher P, Goerdt S. (2012) Unique cell type-specific junctional complexes in vascular endothelium of human and rat liver sinusoids. PLoS One. 7(4):e34206. (projects C3, B5)

 

Buurman R, Gürlevik E, Schäffer V, Eilers M, Sandbothe M, Kreipe H, Wilkens L, Schlegelberger B, Kühnel F, Skawran B. (2012) Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells. Gastroenterology. 143(3):811-20.e1-15 (projects B1, B2, C7)

 

Urbanik T, Boger RJ, Longerich T, Becker K, Ehrenberg KR, Hövelmeyer N, Hahn M, Schuchmann M, Jäger D, Waisman A, Wörns MA, Schulze-Bergkamen H. (2012) Liver specific deletion of CYLDexon7/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice. 57(5):995-1003 (project Schulze-Bergkamen)

 

 

AWARDS & HONORS 2011:



TOP PUBLICATIONS 2011



TOP PUBLICATIONS 2010
Gürlevik E, Woller N, Strüver N, Schache P, Kloos A, Manns MP, Zender L, Kühnel F, Kubicka S (2010) Selectivity of oncolytic viral replication prevents antiviral immune response and toxicity, but does not improve antitumoral immunity. Mol Ther. 18(11):1972-82 (C7, A4, B4)


U. Kossatz, K. Breuhahn, B. Wolf
, M. Hardtke-Wolenski, L. Wilkens, D. Steinemann, S. Singer, F. Brass, S. Kubicka, B. Schlegelberger, P. Schirmacher, M.P. Manns, J.D. Singer, N.P. Malek (2010) The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor initiating cells. J Clin Invest 120(11):3820-33 (A4,B2,B4,B5,B7,B8)

B. Denecke, L. Wickert, Y. Liu, L. Ciuclan, S. Dooley, N.M. Meindl-Beinker (2010). Smad7 dependent expression signature highlights BMP2 and HK2 signaling in HSC transdifferentiation. World J Gastroenterol; 16(41):5211-24 (A6)

Boozari B, Mundt B, Woller N, Strüver N, Gürlevik E, Schache P, Kloos A, Knocke S, Manns MP, Wirth TC, Kubicka S, Kühnel F. (2010) Antitumoural immunity by virus-mediated immunogenic apoptosis inhibits metastatic growth of hepatocellular carcinoma. Gut. 59(10):1416-26 (A4, C2, C7)

Kalthoff S, Ehmer U, Freiberg N, Manns MP, Strassburg CP. (2010) Coffee induces expression of glucuronosyltransferases via the aryl hydrocarbon receptor and Nrf2 in liver and stomach. Gastroenterology. 139(5):1699-710 (A4)


Haile LA, Gamrekelashvili J, Manns MP, Korangy F, Greten TF (2010) CD49d Is a New Marker for Distinct Myeloid-Derived Suppressor Cell Subpopulations in Mice. J Immunol. 4(3):345-53 (A4, C2)

Vosskuhl K, Greten TF, Manns MP, Korangy F, Wedemeyer J. (2010) Lipopolysaccharide-Mediated Mast Cell Activation Induces IFN- Secretion by NK Cells. J Immunol. 185(1):119-25. (A4, C2)

Greten TF, Forner A, Korangy F, N'kontchou G, Barget N, Ayuso C, Ormandy LA, Manns MP, Beaugrand M, Bruix J. (2010) A phase II open label trial evaluating safety and efficacy of a telomerase peptide vaccination in patients with advanced hepatocellular carcinoma. BMC Cancer. 10(1):209. (A4, C2)

Schuster A, Schilling T, De Laurenzi V, Koch A, Seitz S, Staib F, Teufel A, Thorgeirsson SS, Galle PR, Melino G, Stremmel W, Krammer PH, Müller M (2010) ΔNp73ß is oncogenic in hepatocellular carcinoma by blocking apoptosis signaling via death receptors and mitochondria. Cell Cycle 9(13) (A2, B6)

Bantel H, Simon HU (2010) Comments on Schuster et al: DeltaNp73beta is oncogenic in hepatocellular carcinoma by blocking apoptosis signaling via death receptors and mitochondria. Cell Cycle 9(14):2710-1. (C1)

 

C. Geraud, K. Schledzewski, A. Demory, D. Klein, M. Kaus, F. Peyre, C. Sticht, K. Evdokimov, S. Lu, A. Schmieder, and S. Goerdt (2010) Liver sinusoidal endothelium: a microenvironment dependent differentiation program in rat including the novel junctional protein Leda-1. Hepatology 52(1):313-26 (Project C3)

Ciuclan L, Ehnert S, Ilkavets I, Weng HL, Gaitantzi H, Tsukamoto H, Ueberham E, Meindl-Beinker NM, Singer MV, Breitkopf K, Dooley S. (2010) TGF-beta enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I. J Hepatol 52(3):407-16 (Project A7)

Pellegrino R, Calvisi DF, Ladu S, Ehemann V, Staniscia T, Evert M, Dombrowski F, Schirmacher P, Longerich T. (2010) Oncogenic and tumor suppressive roles of polo-like kinases in human hepatocellular carcinoma. Hepatology 51(3):857-68 (Project B5)

Erichsen TJ, Aehlen A, Ehmer U, Kalthoff S, Manns MP, Strassburg CP. (2010) Regulation of the human bile acid UDP-glucuronosyltransferase 1A3 by the farnesoid X receptor and bile acids J Hepatol 52(4):570-8 (Project A4)

Kalthoff S, Ehmer U, Freiberg N, Manns MP, Strassburg CP. (2010) Interaction between oxidative stress sensor Nrf2 and xenobiotic-activated aryl hydrocarbon receptor in the regulation of the human phase II detoxifying UDP-glucuronosyltransferase 1A10 J Biol Chem 285(9):5993-6002 (Project A4)

Backes P, Quinkert D, Reiss S, Binder M, Zayas M, Rescher U, Gerke V, Bartenschlager R, Lohmann V. (2010) Role of annexin A2 in the production of infectious hepatitis C virus particles. J Virol. 84(11):5775-89 (Project A1)

Weber A, Boger R, Vick B, Urbanik T, Haybaeck J, Zoller S, Teufel A, Krammer PH, Opferman JT, Galle PR, Schuchmann M, Heikenwalder M, Schulze-Bergkamen H. (2010) Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice. Hepatology 51(4):1226-36. (associated project)

Kühnel F, Gürlevik E, Wirth TC, Strüver N, Malek NP, Müller-Schilling M, Manns MP, Carnero A, Zender L, Kubicka S. (2010) Targeting of p53-transcriptional dysfunction by conditionally replicating adenovirus is not limited by p53-homologues. Mol Ther 18(5):936-46 (Project C7)

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