Latest Publications
2021
Rappez L&, Stadler M&, Triana S, Gathungu RM, Ovchinnikova K, Phapale P, Heikenwalder M*, Aelxandrov T* (2021). SpaceM reveals metabolic states of single cells. Nat Methods 18:799-805.&co-first authors, *co-last, co-corresponding author.
Deczkowska A, David E, Ramadori P, Pfister D, Safran M, At The B, Giladi A, Jaitin DA, Barboy O, Cohen M, Yofe I, Gur C, Shlomi-Loubaton S, Henri S, Suhail Y, Qiu M, Kam S, Hermon H, Lahat E, Ben-Yakov G, Cohen-Ezra O, Davidov Y, Likhter M, Goitein D, Roth S, Weber A, Malissen B, Weiner A*, Ben-Ari Z*, Heikenwalder M*, Elinav E*, Amit I* (2021). XCR1+ type 1 conventional dendritic cells drive liver pathology in Non-Alcoholic Steatohepatitis. Nat Med 27:1043-1054. *co-last, co-corresponding author.
Pfister D, Gonzalo Núñez N, Pinyol R, Govaere O, Pinter M, Szydlowska M, Gupta R, Qiu M, Deczkowska A, Weiner A, Müller F, Sinha A, Friebel E, Engleitner T, Lenggenhager D, Heide D, Stirm K, Kosla J, Youssuf S, Dudek M, Kotsiliti E, Ramadori P, Yahoo N, Leone V, Inverso D, Singh I, Castet F, Montironi C, Haber PK, Tiniakos D, Bedossa P, Cockell S, Younes R, Vacca M, Marra F, Schattenberg JM, Allison M, Bugianesi E, Ratziu V, Pressiani T, D'Alessio A, Personeni N, Rimassa L, Daly AK, Scheiner B, Pomej K, Kirstein MM, Vogel A, Peck-Radosavljevic M, Hucke F, Finkelmeier F, Waidmann O, Trojan J, Schulze K, Wege H, Koch S, Weinmann A, Bueter M, Rössler F, Müllhaupt B, Siebenhüner A, De Dosso S, Jugold M, Luedde T, Schietinger A, Schirmacher P, Augustin HG, Billeter A, Müller-Stich B, Wolter K, Zender L, Mei HE, Schulz AR, Ringelhan M, Malek N, Spahn S, Bitzer M, Lujambio A, Rahbari N, Dufour JF, Marron TU, Kaseb A, Kudo M, Huang YH, Teijeiro A, Djouder N, Weber A, Marche PN, Pinato DJ, Decaens T, Macek Jilkova Z, Rad R, Mertens JC, Unger K, Meissner F, Roth S, Claassen M, Anstee QM, Amit I, Becher B, Knolle P, Llovet JM*, Heikenwalder M* (2021) NASH limits anti-tumor surveillance in immunotherapy-treated hepatocellular carcinoma. Nature 592:450-456. *equal contribution.
Gengenbacher H, Singhal M, Mogler C, Hai L, Milde L, Abdul Pari AA, Besemfelder E, Fricke C, Baumann D, Gehrs S, Utikal J, Felcht M, Hu J, Schlesner M, Offringa R, Chintharlapalli SR, Augustin HG (2021) Timed Ang2-targeted therapy identifies the Angiopoietin-Tie pathway as key regulator of fatal lymphogenous metastasis. Cancer Discov 11:424-445.
Winkler M, Staniczek T, Kürschner SW, Schmid CD, Schönhaber H, Cordero J, Kessler L, Mathes A, Sticht C, Neßling M, Uvarovskii A, Anders S, Zhang XJ, von Figura G, Hartmann D, Mogler C, Dobreva G, Schledzewski K, Géraud C, Koch PS, Goerdt S (2021) Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling. J Hepatol 74:380-393.
Roessler S, Edeline J, Schirmacher P*, Coulouarn C* (2021) Integrative genomics highlights opportunities for innovative therapies targeting the tumor microenvironment in gallbladder cancer. J Hepatol 74:1018-1020. *equal contribution.
Goeppert B, Stichel D, Toth R, Fritzsche S, Loeffler MA, Schlitter AM, Neumann O, Assenov Y, Vogel MN, Mehrabi A, Hoffmann K, Köhler B, Springfeld C, Weichenhan D, Plass C, Esposito I, Schirmacher P, von Deimling A, Roessler S (2021) Integrative analysis reveals early and distinct genetic and epigenetic changes in intraductal papillary and tubulopapillary cholangiocarcinogenesis. Gut. doi: 10.1136/gutjnl-2020-322983.
Kendre G, Marhenke S, Lorz G, Kühnel F, Woller N, Reineke-Plaaß T, Poth T, Becker D, Marquardt JU, Wirtz RM, Bonin M, Saborowski M, Vogel A*, Saborowski A* (2021). The co-mutational spectrum determines the therapeutic response in murine FGFR2 fusion - driven cholangiocarcinoma. Hepatology. doi: 10.1002/hep.31799. *equal contribution.
Filali-Mouncef Y*, Hunter C*, Roccio F*, Zagkou S*, Dupont N, Primard C, Proikas-Cezanne T, Reggiori F (2021) The ménage à trois of autophagy, lipid droplets and liver disease. Autophagy. doi: 10.1080/15548627.2021.1895658. *equal contribution.
Buitrago-Molina LE, Marhenke S, Becker D, Geffers R, Itzel T, Teufel A, Jaeschke H, Lechel A, Unger K, Markovic J, Sharma AD, Marquardt JU, Saborowski M, Saborowski A*, Vogel A* (2021). p53-independent induction of p21 fails to control regeneration and hepatocarcinogenesis in a murine liver injury model. Cell Mol Gastroenterol Hepatol 11:1387-1404. *equal contribution.
Pellegrino R, Thavamani A, Calvisi DF, Budczies J, Neumann A, Geffers R, Kroemer J, Greule D, Schirmacher P, Nordheim A, Longerich T (2021) Serum Response Factor (SRF) drives the transcriptional upregulation of the MDM4 oncogene in HCC. Cancers (Basel) 13:199.
Dudek M, Pfister D, Donakonda S, Filpe P, Schneider A, Laschinger M, Hartmann D, Hüser N, Meiser P, Bayerl F, Inverso D, Wigger J, Sebode M, Öllinger R, Rad R, Roth S, Hegenbarth S, Anton M, Guillot A, Bowman A, Heide D, Müller M, Garcia Caceres C, Gruber T, Seifert G, Kabat A, Malm JP, Effenberger R, Billeter A, Müller-Stich B, Pearce EJ, Koch-Nolte F, Käser R, Tilg H, Thimme R, Böttler T, Tacke F, Dufour JF, Haller D, Murray P, Heeren R, Zehn D, Böttcher J, Heikenwalder M, Knolle P (2021) CXCR6 PD-1hiCD8 T cells cause liver immune pathology after metabolic activation in non-alcoholic steatohepatitis. Nature 592:444-449.
Mohs A, Otto T, Schneider KM, Peltzer M, Boekschoten M, Holland CH, Hudert CA, Kalveram L, Wiegand S, Saez-Rodriguez J, Longerich T, Hengstler JG, Trautwein C (2021) Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis. J Hepatol 74:638-648.
Rappez L&, Stadler M&, Triana S, Gathungu RM, Ovchinnikova K, Phapale P, Heikenwalder M*, Aelxandrov T* (2021). SpaceM reveals metabolic states of single cells. Nat Methods 18:799-805.&co-first authors, *co-last, co-corresponding author.
Deczkowska A, David E, Ramadori P, Pfister D, Safran M, At The B, Giladi A, Jaitin DA, Barboy O, Cohen M, Yofe I, Gur C, Shlomi-Loubaton S, Henri S, Suhail Y, Qiu M, Kam S, Hermon H, Lahat E, Ben-Yakov G, Cohen-Ezra O, Davidov Y, Likhter M, Goitein D, Roth S, Weber A, Malissen B, Weiner A*, Ben-Ari Z*, Heikenwalder M*, Elinav E*, Amit I* (2021). XCR1+ type 1 conventional dendritic cells drive liver pathology in Non-Alcoholic Steatohepatitis. Nat Med 27:1043-1054. *co-last, co-corresponding author.
Pfister D, Gonzalo Núñez N, Pinyol R, Govaere O, Pinter M, Szydlowska M, Gupta R, Qiu M, Deczkowska A, Weiner A, Müller F, Sinha A, Friebel E, Engleitner T, Lenggenhager D, Heide D, Stirm K, Kosla J, Youssuf S, Dudek M, Kotsiliti E, Ramadori P, Yahoo N, Leone V, Inverso D, Singh I, Castet F, Montironi C, Haber PK, Tiniakos D, Bedossa P, Cockell S, Younes R, Vacca M, Marra F, Schattenberg JM, Allison M, Bugianesi E, Ratziu V, Pressiani T, D'Alessio A, Personeni N, Rimassa L, Daly AK, Scheiner B, Pomej K, Kirstein MM, Vogel A, Peck-Radosavljevic M, Hucke F, Finkelmeier F, Waidmann O, Trojan J, Schulze K, Wege H, Koch S, Weinmann A, Bueter M, Rössler F, Müllhaupt B, Siebenhüner A, De Dosso S, Jugold M, Luedde T, Schietinger A, Schirmacher P, Augustin HG, Billeter A, Müller-Stich B, Wolter K, Zender L, Mei HE, Schulz AR, Ringelhan M, Malek N, Spahn S, Bitzer M, Lujambio A, Rahbari N, Dufour JF, Marron TU, Kaseb A, Kudo M, Huang YH, Teijeiro A, Djouder N, Weber A, Marche PN, Pinato DJ, Decaens T, Macek Jilkova Z, Rad R, Mertens JC, Unger K, Meissner F, Roth S, Claassen M, Anstee QM, Amit I, Becher B, Knolle P, Llovet JM*, Heikenwalder M* (2021) NASH limits anti-tumor surveillance in immunotherapy-treated hepatocellular carcinoma. Nature 592:450-456. *equal contribution.
Gengenbacher H, Singhal M, Mogler C, Hai L, Milde L, Abdul Pari AA, Besemfelder E, Fricke C, Baumann D, Gehrs S, Utikal J, Felcht M, Hu J, Schlesner M, Offringa R, Chintharlapalli SR, Augustin HG (2021) Timed Ang2-targeted therapy identifies the Angiopoietin-Tie pathway as key regulator of fatal lymphogenous metastasis. Cancer Discov 11:424-445.
Winkler M, Staniczek T, Kürschner SW, Schmid CD, Schönhaber H, Cordero J, Kessler L, Mathes A, Sticht C, Neßling M, Uvarovskii A, Anders S, Zhang XJ, von Figura G, Hartmann D, Mogler C, Dobreva G, Schledzewski K, Géraud C, Koch PS, Goerdt S (2021) Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling. J Hepatol 74:380-393.
Roessler S, Edeline J, Schirmacher P*, Coulouarn C* (2021) Integrative genomics highlights opportunities for innovative therapies targeting the tumor microenvironment in gallbladder cancer. J Hepatol 74:1018-1020. *equal contribution.
Goeppert B, Stichel D, Toth R, Fritzsche S, Loeffler MA, Schlitter AM, Neumann O, Assenov Y, Vogel MN, Mehrabi A, Hoffmann K, Köhler B, Springfeld C, Weichenhan D, Plass C, Esposito I, Schirmacher P, von Deimling A, Roessler S (2021) Integrative analysis reveals early and distinct genetic and epigenetic changes in intraductal papillary and tubulopapillary cholangiocarcinogenesis. Gut. doi: 10.1136/gutjnl-2020-322983.
Kendre G, Marhenke S, Lorz G, Kühnel F, Woller N, Reineke-Plaaß T, Poth T, Becker D, Marquardt JU, Wirtz RM, Bonin M, Saborowski M, Vogel A*, Saborowski A* (2021). The co-mutational spectrum determines the therapeutic response in murine FGFR2 fusion - driven cholangiocarcinoma. Hepatology. doi: 10.1002/hep.31799. *equal contribution.
Filali-Mouncef Y*, Hunter C*, Roccio F*, Zagkou S*, Dupont N, Primard C, Proikas-Cezanne T, Reggiori F (2021) The ménage à trois of autophagy, lipid droplets and liver disease. Autophagy. doi: 10.1080/15548627.2021.1895658. *equal contribution.
Buitrago-Molina LE, Marhenke S, Becker D, Geffers R, Itzel T, Teufel A, Jaeschke H, Lechel A, Unger K, Markovic J, Sharma AD, Marquardt JU, Saborowski M, Saborowski A*, Vogel A* (2021). p53-independent induction of p21 fails to control regeneration and hepatocarcinogenesis in a murine liver injury model. Cell Mol Gastroenterol Hepatol 11:1387-1404. *equal contribution.
Pellegrino R, Thavamani A, Calvisi DF, Budczies J, Neumann A, Geffers R, Kroemer J, Greule D, Schirmacher P, Nordheim A, Longerich T (2021) Serum Response Factor (SRF) drives the transcriptional upregulation of the MDM4 oncogene in HCC. Cancers (Basel) 13:199.
Dudek M, Pfister D, Donakonda S, Filpe P, Schneider A, Laschinger M, Hartmann D, Hüser N, Meiser P, Bayerl F, Inverso D, Wigger J, Sebode M, Öllinger R, Rad R, Roth S, Hegenbarth S, Anton M, Guillot A, Bowman A, Heide D, Müller M, Garcia Caceres C, Gruber T, Seifert G, Kabat A, Malm JP, Effenberger R, Billeter A, Müller-Stich B, Pearce EJ, Koch-Nolte F, Käser R, Tilg H, Thimme R, Böttler T, Tacke F, Dufour JF, Haller D, Murray P, Heeren R, Zehn D, Böttcher J, Heikenwalder M, Knolle P (2021) CXCR6 PD-1hiCD8 T cells cause liver immune pathology after metabolic activation in non-alcoholic steatohepatitis. Nature 592:444-449.
Mohs A, Otto T, Schneider KM, Peltzer M, Boekschoten M, Holland CH, Hudert CA, Kalveram L, Wiegand S, Saez-Rodriguez J, Longerich T, Hengstler JG, Trautwein C (2021) Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis. J Hepatol 74:638-648.