Area B

Research Area B aims at the definition of novel protumorigenic mechanisms by two different means: a) unbiased broad spectrum analyses with a key reference to epigenetic/non-coding RNA function (B1-B4) and b) projects that address key basic mechanisms (e.g., p53, cell division, transcriptional regulation; B5-B8)


B1: Epigenetic Profiling of Human Hepatocellular Carcinoma (Lehmann/Kreipe)


B2: Functional Consequences of Altered microRNA Expression Induced by Histone Deacetylation in Hepatocellular Carcinoma (Skawran/Schlegelberger)


B3: Non-coding RNAs in Hepatocellular Carcinoma (Diederichs)


B4: RNAi Screening for Synthetic Lethalities and Treatment Response Modifiers of Targeted Therapies in Hepatocellular Carcinoma (Zender/Geffers)


B5: Dysregulation of p53 by MDM Proteins in Human Hepatocarcinogenesis (Longerich/Radlwimmer/Schirmacher)

B7: Transcription Factor-Dependent Regulation of HCC Growth and Migration (Breuhahn)

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